Fever ‘n flu sachets

Description

PROPERTIES:
Fever ‘n flu sachets contain paracetamol which possesses analgesic and antipyretic properties. Paracetamol reduces fever by a direct action on the hypothalamic heat-regulating centers. Paracetamol is equal to aspirin in analgesic and antipyretic effectiveness and it is unlikely to produce the side effects often associated with aspirin. Vitamin C activates the defensive mechanism of the body. Phenylephrine is a sympathomimetic agent which stimulates adrenergic receptors in the mucous membranes of the upper respiratory tract, specially the nasal mucosa and sinuses causing rapid nasal decongestion, relief of nasal mucosal edema and reduction of sinuses secretion. Thus, the combination of these three active ingredients renders Fever ‘n flu the perfect choice for the treatment of common cold accompanied by fever, pain and nasal congestion.
PHARMACOKINTETICS:
– Paracetamol is readily absorbed from gastrointestinal tract with peak plasma concentration occurring about 10 to 60 minutes after oral doses.
– Paracetamol is distributed into most body tissues, it crosses the placenta and is present in breast milk.
– Paracetamol plasma protein binding is negligible at usual therapeutic concentrations. The elimination half-life varies about 1 to 3 hours.
– Paracetamol is metobolised predoninantly in the liver and excreted in the urine mainly as glucuronide and sulfate conjugates.
– Ascorbic acid is readily absorbed from the gastrointestinal tract and is widely distributed in the body tissues.
– Ascorbic acid in excess of the body needs is rapidly eliminated unchanged in the urine.
– Ascorbic acid crosses the placenta and is distributed into breast milk.
– Phenylephrine has low oral bioavailability owing to irregular absorption and first pass metabolism by monoamine oxidase in the gut and liver.

INDICATIONS:
Relief of common cold symptoms such as nasal congestion, runny nose, sore throat, sneezing, minor aches, pains, headaches and fever.
DOSAGE:
Empty contents of one sachet into a mug. Half fill with very hot water. Stir well. Add cold water as necessary and sugar if desired.
Adults and children aged 12 years and over:
One sachet to be taken every four hours as necessary up to a maximum of 6 sachets in 24 hours. Do not give to children under 12 years.
SIDE EFFECTS:
As with other sympathomimetics, tachycardia, restlessness and insomnia may occur.
CONTRAINDICATIONS:
Hyperthyroidism, diabetes mellitus, ischemic heart disease and hypertension. Should not be given to patients receiving MAOI or within 14 days of its termination.
DRUG INTERACTIONS:
Should not be used with other products containing paracetamol.
PREGNANCY & LACTATION:
If you are pregnant or nursing a baby, seek the advice of a health professional before using this product.
PRECAUTIONS:
Should not be administered for more than 5 days for pain and 3 days for fever unless directed by a doctor. The maximum daily dose for paracetamol is 4 gm. If sore throat is severe, persists for more than 2 days, is accompanied by fever, headache, rash, nausea or vomiting consult a doctor.
INSTRUCTIONS TO PATIENTS:
Do not exceed recommended dosage.
PACKING:
A carton box containing 6 sachets.
STORAGE:
Keep at a temperature not exceeding 30º C, in dry place.
Keep out of reach of children.