UR-AID SACHET

Description

PROPERTIES:
URAID effervescent granules Is a multi-functional formulation combining three active ingredients which act in harmony with multiple complementary activities for the management of acute attacks of gout and for promoting urinary excretion of uric acid. Piperazine acts by dissolving uric acid thus preventing its deposition in the urinary tract. This property ensures the effectiveness of URAID in treatment of gout and urinary urate lithiasis. Atropine sulfate is an antispasmodic which relieves urethric spasms accompanying urinary washout of urate crystals. URAID also contains colchicine that provides prompt relief of pain in gouty attacks. In addition, URAID causes an increase in urine pH and is well tolerated by all patients. All these properties ensure effective relief of acute attacks of gout and facilitate rapid excretion of urates in a more soluble form.
PHARMACOKINETICS:
Piperazine is readily absorbed from gastrointestinal tract and is excreted in the urine within 24 hours partly as metabolites.
Atropine is readily absorbed from gastro intestinal tract.
It is rapidly cleared from blood and distributed throughout the body it crosses blood brain barrier. It is incompletely metabolized in the liver and is excreted in the urine as unchanged drug and metabolites.
Peak plasma concentrations of colchicines are reached within 2 hours of oral use. Colchicine is partially deacetylated in the liver and the unchanged drug and its metabolites are excreted in the bile and under intestinal reasport.
Most of the drug in excreted in feaces but 10 to 20% excreted in urine.

INDICATIONS:
• Acute gout and short-term prophylaxis during initial therapy with allopurinol and uricosuric drugs.
• Prophylaxis against urinary urate stones.
DOSAGE:
The contents of one sachet are dissolved in half a glass of water and taken before meals three times daily or as prescribed by the physician.
CONTRAINDICATIONS:
Narrow-angle glaucoma, myasthenia gravis, paralytic ileus, pyloric stenosis, prostatic enlargement.
SIDE EFFECTS:
URAID is safe and well tolerated. Mild side effects such as nausea, dry mouth and abdominal pain may occur in some patients, peripheral neuritis, myopathy, headache, urticaria.
DRUG INTERACTIONS:
1. Acute myopathy has been reported in patients with chronic renal impairment given colchicines ith simvastatin, fluvastatin or pravastatin.
2. Increase blood ciclosporin concentrations and nephrotoxicity developed in a renal transplant patient after the introduction of colchicine therapy.
3. The effect of atropine may be enhanced by concomitant use of other drugs with antimuscarinic properties such as amantadine, some antihistamines, phenothiazine antipsychotics and tricylic antidepressant.
Inhibition of drug metabolizing enzymes by MAOIs may possibly enhance the effect of antimuscarinic.
Antimiscarinics may also antagonize the gastrointestinal effect of cisapride, domeperidone and metoclopramide.
Antimus carines and para sympathonimetics may counteract each other effects.
PREGNANCY & LACTATION:
URAID is contraindicated in pregnancy and lactation
WARNING & PRECAUTIONS:
• URAID should be given with great care to elderly or debilitated patients who may particularly susceptible to cumulative toxicity.
• Caution should be taken in patients who complaining of hypertension, heart failure, renal disease, oedema and all cases that need salt restriction.
• URAID should be avoided in patients with blood disorders.
• URAID is contraindicated in patients with epilepsy or severe renal impairment and should be given with care to patients with neurological disturbances or mild to moderate renal impairment.
• URAID is contraindicated in patients with prostatic enlargement in whom it may lead to urinary retention and in those with paralytic ileus or pyloric stenosis.
• The product should be used with caution in reflux oesophagitis, ulcerative colitis, acute myocardial infarction, hypertension and conditions characterized by tachycardia.
• It is not recommended not to exceed the recommended dose to prevent occurrence of side effects in the nervous system especially in patients with renal disease.
• It is not used in case of glaucoma and increase in intraocular pressure.
PATIENT INFORMATION:
Not to be used except under medical supervision and not to be dispensed except with a medical prescription.
PACKING:
A carton box containing 12 sachets with a pamphlet.
STORAGE:
Keep at a temperature not exceeding 30°C in dry place.
Keep out of reach of children.