MAXA-FLOX

Description

PROPERTIES:
MAXA-FLOX eye drops contains lomefloxacin, a difluorinated quinolone derivative which is therapeutically effective in the treatment of bacterial infections of the anterior segment of the eye. MAXA-FLOX eye drops exerts a bactericidal effect against a wide range of Gram-positive and Gram-negative bacteria. Lomefloxacin acts on the A subunit of bacterial DNA gyrase (topoisomerase II) leading to impaired enzyme functions. MAXA-FLOX eye drops therefore inhibits bacterial DNA-related processes resulting in rapid killing of sensitive bacteria. The topical application of MAXA-FLOX eye drops is indicated in eye superficial bacterial infections to achieve rapid and complete microbiological and clinical cure.
PHARMACOKINETICS:
Following topical application of MAXA-FLOX eye drops, lomefloxacin systemic absorption is very low and the blood levels of the drug are undetectable.
ANTIMICROBIAL SPECTRUM:
Lomefloxacin is active against many Gram-positive and Gram-negative bacteria involved in conjunctival and corneal ulcer infections. The antimicrobial spectrum of the drug includes:
– Gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Enterococcus faecalis.
– Gram-negative bacteria: Haemophilus influenzae, Proteus mirabilis,Pseudomonas aeruginosa, Serratia marcescens, Moraxella catarrhalis, Neisseria gonorrhoeae, Enterobacter species.
INDICATIONS:
• Treatment of bacterial infections of the anterior segment of the eye as in:
– Conjunctivitis.
– Blepharitis, blepharoconjunctivitis.
– Keratitis, keratoconjunctivitis.
– Infected corneal ulcer.
– Dacryocystitis.
• Prophylaxis of eye bacterial infection:
– Before and after eye surgery,
– Following removal of a foreign body from the eye.
DOSAGE & ADMINISTRATION:
– Instill 1 drop of MAXA-FLOX into the lower conjunctival sac, 2-3 times daily or as directed by the physician
– At the beginning of treatment, the application should be more frequent: Apply 5 drops of MAXA-FLOX within 20 minutes or 1 drop every hour during the first 6-10 hours or as directed by the physician.
– Duration of treatment: 7-9 days.
CONTRAINDICATIONS:
Hypersensitivity to any component of the product.
SIDE EFFECTS:
MAXA-FLOX eye drops is safe and well tolerated. However, mild and transient burning sensation in the eye may occur immediately after instillation of the drops.
DRUG INTERACTIONS:
Bacteriostatic ophthalmic antibiotic preparations should not be used concomitantly with MAXA-FLOX eye drops.
PREGNANCY & LACTATION:
The drug should only be used during pregnancy and lactation when indicated and as directed by the physician.
PRECAUTIONS & WARNINGS:
Long-term treatment with antimicrobial agents may enhance the development of secondary fungal infections or the growth of resistant bacteria.
PACKING:
A dropper bottle containing 5 ml of MAXA-FLOX eye drops.
STORAGE:
Keep at temperature not exceeding 30C.
Keep out of reach of children.
INSTRUCTIONS TO PATIENTS:
– Do not touch the dropper tip, as this may contaminate the contents.
– Close the bottle immediately after each use.
– Contact lenses should not be worn during the use of this product.