SPECTRAGYN SUPPOSITORY

Description

Pharmacological action:
spectragyn vaginal suppositories contain four active ingredients which act synchronously for treatment of vaginal or vulvovaginal inflammatory conditions associated with protozoal or microbial infections. Metronidazole, the first ingredient in spectragyn, is an effective agent for the prophylaxis and treatment of vaginal protozoal infections as Trichomonas vaginalis. It also possesses bactericidal action on many anaerobic microorganisms such as Bacteroids spp., Gardnerella vaginalis, Mobiluncus spp. and Peptostreptococcus spp. Neomycin, the second ingredient in spectragyn, is an aminoglycoside antibiotic known by its highly effective bactericidal effect against a wide variety of Gram-negative and Gram-positive bacteria. Nystatin, the third ingredient in spectragyn, is an antifungal agent known by its high efficacy against many yeasts and yeast-like fungi including Candida species. Hydrocortisone, the fourth ingredient in spectragyn, is a corticosteroid with prompt antiallergic, antipruritic and anti-inflammatory actions with minimal side effects. spectragyn, in the form of vaginal suppositories, has the advantage of exerting rapid symptomatic relief of pruritus and burning sensation accompanying vaginal infections. Therefore, spectragyn provides a wide range of therapeutic effects with excellent patient compliance. In addition, spectragyn, in the form of vaginal suppositories, is highly safe as its ingredients act topically in the vagina with a little systemic absorption.
Pharmacokinetics:
spectragyn vaginal suppositories act locally, with minimum systemic absorption.
INDICATIONS:
spectragyn, in the form of vaginal suppositories, is highly effective in the treatment of vaginitis due to different causes as in:
ϖ Leukorrhea with itching and burning sensation in the vagina and vulva specially when candidal or bacterial infection is suspected.
ϖ Bacterial vaginitis including cases due to anaerobic bacteria (anaerobic vaginosis).
ϖ Trichomonas vaginitis.
ϖ Vaginal or vulvovaginal candidiasis.
ϖ Mixed vaginal infections causes by Trichomonas vaginalis, fungi and / or bacteria.
DOSAGE and administration:
One spectragyn vaginal suppositories is to be inserted deeply into the vagina once (at bedtime) or twice daily for 5-10 consecutive days or as prescribed by the physician. The treatment should be maintained for the recommended duration even if menstruation occurs.
Contraindications:
Hypersensitivity to any component of the product.
side effects:
spectragyn vaginal suppositories are safe and well tolerated. Rarely, transient local itching and vaginal irritation may occur at the beginning of treatment.
Drug interactions:
Because of poor systemic absorption of the components following vaginal application, the possibilities of drug interactions are minimal.
Pregnancy & lactation:
spectragyn vaginal suppositories are not recommended during pregnancy and lactation.
Precautions & warnings:
Discontinue the treatment and consult your physician if severe local irritation or sensitization occurs.
PACKING:
A box containing 10 spectragyn vaginal suppositories in 2 PVC-PE strips, each of 5 spectragyn vaginal suppositories.
STORAGE:
Keep at a temperature not exceeding 30C.
Keep out of reach of children.
instruction to patients:
It is advisable that the patient lies on her back for at least 15 minutes after administration of spectragyn vaginal suppositories